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RNA Interference by Patrick J. Paddison

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Published by Springer-Verlag Berlin Heidelberg in Berlin, Heidelberg .
Written in English


  • Medicine,
  • Human genetics

Book details:

Edition Notes

Statementedited by Patrick J. Paddison, Peter K. Vogt
SeriesCurrent Topics in Microbiology and Immunology -- 320
ContributionsVogt, P. K. (Peter K.), 1932-, SpringerLink (Online service)
The Physical Object
Format[electronic resource] /
ID Numbers
Open LibraryOL25539449M
ISBN 109783540751564, 9783540751571

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“The book provides a broad overview of RNA chemistry, the pharmacology and the manipulation of signaling pathways by using RNA interference. This book is very well written and will be an asset to any researcher who uses RNA interference as a tool to study gene function. and will probably mainly be of use to researcher already working Author: Wei-Ping Min.   RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses extensive methodology related to delivery methods high throughput strategies and . The final chapters of the book detail the application of RNAi to dissect gene function in a number of biological systems, including cell-free systems, cultured cells, and whole organisms. This book is a comprehensive guide to gene silencing by RNA interference methods for beginners and experienced professionals in the field.   The Nobel Prize in Physiology or Medicine was awarded to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference (RNAi). RNAi is a biological process in which RNA molecules can silence (inhibit) or up- or down-regulate gene expression, typically by causing the destruction of specific messenger RNA (mRNA) :

Robert E. Farrell Jr. Ph.D, in RNA Methodologies (Fourth Edition), Publisher Summary. RNA interference (RNAi) is a naturally occurring mechanism for gene silencing induced by the presence of short interfering RNA (siRNA). RNAi is an endogenous catalytic pathway that is triggered by double-stranded RNA (dsRNA). The trigger can occur naturally, as in the case of a cellular infection by a. RNA Interference (RNAi) Introduction. RNA interference or Post-Transcriptional Gene Silencing is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding natural mechanism for sequence-specific gene silencing promises to revolutionize. "The use of RNA interference to control gene expression is emerging as an exciting new technology. The potential of this mechanism depends on the ability to find a competent way to deliver the RNA. This compact book reviews all of these issues in a comprehensive manner." from Doodys (). Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by renowned researchers to provide the most diverse and in-depth examination of the subject yet. This book describes methods and protocols for gene silencing and RNA : $

RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting, and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer, and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods. RNA Interference. Editors: Paddison, Patrick J., Vogt, Peter K. (Eds.) Free Preview. Buy this book eBook ,79 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free; Included format: PDF; ebooks can be used on all reading devices.   + RNA imaging in vivo + Modeling and prediction of RNA structure + RNA microarrays + Aptamer libraries and SELEX technology + RNA interference In short, a guide to successful experimentation for molecular biologists, biochemists and biotechnologists and of interest to every researcher experimenting with RNA. From the early days when RNA interference was a strange artifact in worms to the Noble Prize received by Fire and Mello and the Current clinical trials, the field of RNA interference has grown at a breakneck pace. In RNA Interference: From Biology to Clinical Applications, expert Price: $